Choose the most correct answer from the following questions
1. Which enzyme that was found in MI. a. Troponin b. CKBB c. myoglobin d. LDH
2. All of the following are side effects associated with levothyroxine use, except a. Heat intolerance b. Weight lossc. Irritability. d , Insomnia
3. Which drug produces crystalluria? a. Penicillin b. Sulfamethoxazole c. Doxycycline d. Gentamycin a Candesartan b. Fosinopril
4. Pregnant woman with a chronic hypertensive may be treated as a first choice with ? c. Methyldopa d HHydralazine C. Angiotensin II receptor antagonist
5.valsartan is beta blocker Acei angeotinsen ii r b Diuretics
6. The refrigerator in the pharmacy that is used for storage of pharmaceutical products should be kept at a temperature of : a ) 0-3 ° C b ) 2-8 ° C c ) 5-10 ° C d ) 3-8 ° C
7. Regarding calcium channel blockers a . Verapamil is an antiarrhythmic b. Diltiazem is a dihydropyridine c. amlodipine has a reflex tachycardia d. None of the above
8. Which drug can cause lactic acidosis. a. Glimepiride b. Pioglitazone C. Repaglinide d. Metformin
9. Indicate the drug belonging to proton pump inhibitors. a. Pirenzepine b. Famotidine c. Pantoprazole d Sodium bicarbonate
10. Which of the following is a Leukotriene receptor antagonist. a. lipoxygenase inhibitor b. Tiotropium c. Ipratropium d. zafirlukast
11. Which of the flowing is aminoglycoside antibiotics a- Amoxicillin b- Sulfamethoxazole c- Tetracycline d. Gentamycin e. Clindamycin
12. Nifedipine: a) constricts vascular smooth muscle b) long-acting formulations are preferred in the long-tem treatment of hypertension c) is a nitrate d) results in increased risk of bradycardia when administered concomitantly with atenolol.
13. The management of unstable angina includes all EXCEPT: a) aspirin b) exercise stress test c) clopidogrel d) isosorbide dinitrate
14. To decrease preload and afterload on the heart and thus treat congestive heart failure , we can prescribe : a) beta blockers b) ligoxin c) captopril d) warfarin
15. H2 blocker that is associated with drug – drug Interactions and with anti androgenic side effects : a ) ranitidine b ) lansoprazole c ) cimetidine d ) aluminum hydroxide
16. These drugs are nephrotoxic and ototoxic : a ) penicillins b ) macrolides c) sulphonamides d) aminoglycosides
17. Antibiotic ( s ) that inhibits protein synthesis of bacterial cell is ( are ): Clarithromycin a) C➡ Chloramphenicol b) M⇒ macrolides erythromycine , aziromicine, c) T⇒ Tetracycline doxycycline , minocycline d) All of the above
18. Induction of liver microsomal enzymes can: a) Require the dose increase of some drugs ✓ b) Require the dose decrease of some drugs c) Prolong the duration of the action of a drug d)Intensify the unwanted reaction of a drug
19. Pharmacokinetics are / is: a) Absorphation b) Distribution a en c) Elimintation d) All above
20. Pharmacokinetics significant for: a) Route of addministration b) Dose for absorphation c) Duration of action d ) All above
21. Risk factor for hypertention include : a ) salt intake b ) site of manement c ) Iburofen d ) A and C.
22. Spironolactone induced hyperkalemia is enhanced with : a) Concomitant thiazide b) Concomitant forsumide c) Concomitant amlodipine d) Concomitant captopril
23. The following type of drug – interaction due to Absorption , Metabolism , distribution , Excretion is : a ) pharmacodynamic interaction b ) chemical interaction . c ) phyiscal interaction d ) Pharmacokinetics interaction
24. Drug chough is the most common side effect of the for drug a ) lisinopril b ) candesartan c ) metoprolol d ) tthiazid
25. The dug choice for treatment hypertension with diabetic mullites : a a) bisoprol b) ACEI c) hdralizine. d) fentolamine
26. The term “metabolism” includes the following: a) Transfer of the drug from administration site to systemic circulation b) Binding of substances with plasma proteins c) Accumulation of substances in a tissue d) Process of physicochemical and biochemical alteration of a drug in the body
27. The main site of metabolism is: a) liver b) stomach c) small intestine d) large intestine
28. Metabolism also occurs to a minor extent in the: a) kidneys and lungs. b) blood and skin. c ) a and b . d ) none of the above .
29. Salbutamol used for: a) cardiogenic shock b) epistaxis. c) bronchial asthma d) asthmabronchial
30. which of the following used as antidote for paracetamol poisoning: a) neostigmine b) atropine c) acetylcystiend) d) b and conly
31. which of the following oral hypoglycemic agent belong to biguanides a) insulin b) metformin c ) gliclazid d ) acarbose
32. which of the following an example of diuretic loop : a)HCT-b)torsemide c ) Spironolactone d ) none
33. an example of potassium sparing diuretic : a ) Torsemide b ) spironolactone c ) indapamide d ) b & c are correct .
34. an example of 3rd generation cephalosporin’s : a ) cefadroxil b ) cefotaxime c ) cefpdoxime d ) b & c are correct
35. indicate the competitive antagonist of BZ receptor ( antidote of BZ ): a- flumazenil b- zolpidem c – buspirone e ) None of the above .
36. Exjade is an antidote that is used in case of … a) Iron b) Heparin c) Paracetamol d) Calcium. e ) None of the above .
37. Adrenaline prolongs the action of: a) local anesthetic. b) NSAIDs. c) an antihistamine. d) salbutamol.
38. In an acute angina attack, the patient should be used? a. Isosorbide mononitrate b. Nifedipine c. Nitroglycerin d. PPropranolol
39. The bioavailability of a drug administered directly to systemic circulation is a) 45% b) 100% c) Dependent on the half life of the drug d) Is unpredictable
40. Metformin is used in all of the following, except . a ) Obese b ) Tendency to develop lactic acidosis c ) Serum creatinine less 1.2 mg / dl d ) b and c
41. The prodrugs dexamethasone -21 – B – glucoside and prednisolone – 21 – B glucoside absorbed : a ) in colon efficiently compared to their parent drugs. b) in colon less efficiently compared to their parent drugs. c) in colon more efficiently compared to their parent drugs. d ) none of the above . d ) none of the above
42. mainly used as emergency drug in anaphylactic shock in combination with hydrocortisone or dexamethasone in dextrose solution is : a ) salbutamol . b) phenylephrine. c) ephedrine. d) adrenaline.
43. All of the following drugs may enhance breast milk production by increasing prolactin: a. Haloperidol b. Methyldopa c. Metoclopramide d. Bromocriptine hydrocarbons to carcinogens. d) none of the above
44. Cigarette smoke is responsible for lung and colon cancer because of: a) CYP2D6 metabolizes the polynuclear aromatic hydrocarbons to carcinogens. b) CYP1A2 metabolizes the polynuclear aromatic hydrocarbons to carcinogens. c) CYP 2C19 metabolizes the aromatic polynuclear d)none abobe
45. Oral glucose lowering agents that primarily inhibit the breakdown of glucagon – like peptide 1 are classified as: a) Sulfonylureas b) SGLT2 inhibitors c) DPP-4 inhibitors d) Meglitinides
46. Salbutamol is : a) selective B2 agent. b ) selective B1 agonist . c ) selective a , agonist . d ) non – selective B – agonist .
47. What is the drug which as first line treatment of a parkinsonism: a) Amantadine b) Levodopa c) Pergolide d) Selegiline
48. Phosphate ester of clindamycin to: a) improve absorption. b ) reduce gastric irritation . c) improve taste. d ) none of the above .